FIB-4 Score Calculator

FIB-4 Score - Non-Invasive Liver Fibrosis Assessment

The FIB-4 (Fibrosis-4) Score is a validated non-invasive assessment tool that estimates the degree of liver fibrosis using readily available clinical and laboratory parameters: age, AST (aspartate aminotransferase), ALT (alanine aminotransferase), and platelet count. This simple calculation helps identify patients with significant liver fibrosis or cirrhosis without requiring liver biopsy, making it valuable for screening and monitoring patients with chronic liver disease from various etiologies including viral hepatitis, non-alcoholic fatty liver disease (NAFLD), and alcoholic liver disease. The FIB-4 score stratifies patients into low (<1.45), intermediate (1.45-3.25), and high (>3.25) risk categories for advanced fibrosis, guiding decisions about further evaluation with imaging elastography or liver biopsy. This tool is particularly valuable in primary care and specialty settings where early identification of advanced fibrosis can lead to appropriate specialist referral, hepatocellular carcinoma surveillance initiation, and timely consideration of antiviral or antifibrotic therapies. The FIB-4 score has demonstrated good diagnostic accuracy for excluding advanced fibrosis in patients with low scores and identifying those likely to have cirrhosis with high scores. Serial FIB-4 measurements can track disease progression or improvement over time, making it useful for monitoring treatment response and disease trajectory in chronic liver conditions.